Description

tert-Butyl 4-[(2,6-Difluorophenyl)Methyl]Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a tert-butyloxycarbonyl (Boc) protecting group and a difluorinated aromatic moiety. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of novel drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Research: Used in the research and synthesis of potential protease inhibitors due to its specific piperazine-based structure.
• Kinase Inhibitor Development: Acts as a precursor in the creation of kinase inhibitor libraries for oncology and anti-inflammatory drug discovery.
• Building Block for CNS-Active Compounds: Employed in the synthesis of molecules designed to cross the blood-brain barrier for central nervous system targets.
• Custom Synthesis and Scale-Up: Supplied for custom synthesis projects, from milligram-scale research to kilogram-scale process development and cGMP manufacturing.
• Chemical Biology & Probe Development: Utilized in chemical biology for creating molecular probes to study biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 4-[(2,6-Difluorophenyl)Methyl]Piperazine-1-Carboxylate
CAS No.	1393442-57-3
Molecular Formula	C17H24F2N2O2
Molecular Weight	326.38 g/mol
Synonyms	1-Boc-4-[(2,6-Difluorobenzyl)]piperazine; 4-[(2,6-Difluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2,6-difluorobenzyl)piperazine-1-carboxylate; 1,1-Dimethylethyl 4-[(2,6-difluorophenyl)methyl]-1-piperazinecarboxylate; BOC-4-(2,6-Difluorobenzyl)piperazine; N-Boc-4-(2,6-difluorobenzyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(2,6-Difluorophenyl)Methyl]Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.