Description

3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold with both amino and hydroxy functional groups, protected by a Boc (tert-butoxycarbonyl) group. This compound is a critical building block for medicinal chemists, enabling the synthesis of complex molecules with precise stereochemistry and functional group compatibility. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as neurology and oncology.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the research and synthesis of inhibitors targeting various proteases.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and constructing peptide mimics with enhanced metabolic stability.
• Ligand Synthesis for Drug Discovery: Employed in creating novel ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying enzyme mechanisms and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects in CDMO (Contract Development and Manufacturing Organization) settings.

Basic Information

Product Name	3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1392472-94-4
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl 3-amino-5-hydroxypiperidine-1-carboxylate; 1-Boc-3-amino-5-hydroxypiperidine; 3-Amino-5-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-amino-5-hydroxypiperidine; 3-Amino-5-piperidinol, 1-Boc-protected; Boc-3-Amino-5-hydroxypiperidine; 3-Amino-5-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-3-amino-5-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support customer audits and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.