Description

Bms-955176 is a high-purity, non-steroidal selective glucocorticoid receptor modulator (SGRM) with the CAS number 1392312-45-6. This compound is of significant interest for its potential to dissociate the beneficial anti-inflammatory effects of glucocorticoids from their adverse metabolic side effects. It is primarily utilized by pharmaceutical research and development organizations engaged in metabolic disease, inflammation, and endocrinology research, serving as a critical reference standard and a key intermediate for advanced therapeutic development.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug discovery and manufacturing processes.
• Preclinical Research: Serves as a vital tool compound for in vitro and in vivo studies targeting glucocorticoid receptor pathways.
• Metabolic Disorder Research: Investigated for its potential application in conditions like type 2 diabetes, obesity, and Cushing's syndrome due to its selective receptor modulation.
• Anti-inflammatory Agent Development: Explored for creating novel therapeutics with an improved safety profile for chronic inflammatory diseases.
• Chemical Intermediate: Acts as a sophisticated building block for the synthesis of more complex drug candidates and analogs.
• Mechanistic Studies: Employed in biochemical assays to study receptor-ligand interactions and downstream signaling events.

Basic Information

Product Name	Bms-955176
CAS No.	1392312-45-6
Molecular Formula	C₂₄H₂₈F₂N₄O₃
Molecular Weight	458.50 g/mol
Synonyms	BMS-955176; GRM-1; (11β,16α,17α)-9-Fluoro-11,16,17-trihydroxy-3-oxoandrosta-1,4-diene-2-carbonitrile; LG100268; Selective Glucocorticoid Receptor Modulator 1; 2-Cyano-9-fluoro-11β,16α,17α-trihydroxy-3-oxoandrosta-1,4-diene
EINECS	Contact for details

Quality Control

Every batch of Bms-955176 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS. Our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.