Description

tert-Butyl 3-(Aminomethyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141191) is a high-purity, advanced pharmaceutical intermediate featuring a complex bicyclic pyrazolopyrazine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and research institutions engaged in the discovery of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry. The CAS number for this compound is 1391733-77-9.

Application

This versatile intermediate is engineered for high-value synthesis in regulated environments. Its primary applications include:

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of novel targeted protein degraders.
• Kinase Inhibitor Synthesis: The pyrazolopyrazine core is a privileged structure in the development of selective kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized to create tool compounds for studying specific biological targets and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141191)
CAS No.	1391733-77-9
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	5(4H)-Pyrazolo[1,5-a]pyrazine-5-carboxylic acid, 3-(aminomethyl)-6,7-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 3-(aminomethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate; WX-141191; WX141191; BOC-protected aminomethyl-dihydropyrazolopyrazine; 3-(Aminomethyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester.
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Aminomethyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.