Description

tert-Butyl 3-Amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141188) is a high-purity, advanced pharmaceutical intermediate featuring a fused pyrazolo-pyrazine heterocyclic core. This compound is of significant value for medicinal chemistry research and development, serving as a versatile and critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive amino and protected carboxylate functional groups.
• Heterocyclic Compound Synthesis: Serves as a core scaffold for constructing complex polycyclic nitrogen-containing heterocycles with potential biological activity.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.
• Chemical Biology Probe Development: Utilized in the design and synthesis of chemical probes for target identification and validation in biological systems.

Basic Information

Product Name	tert-Butyl 3-Amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (Wx141188)
CAS No.	1391733-15-5
Molecular Formula	C11H18N4O2
Molecular Weight	238.29 g/mol
Synonyms	5(4H)-Pyrazolo[1,5-a]pyrazinecarboxylic acid, 3-amino-6,7-dihydro-, 1,1-dimethylethyl ester; tert-Butyl 3-aminopyrazolo[1,5-a]pyrazine-5(4H,6H,7H)-carboxylate; WX-141188; WX141188; 3-Amino-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 3-amino-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, generated using validated analytical methods including HPLC, NMR, and MS. We adhere to ICH guidelines for stability and impurity characterization where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.