Description

(3R)-3-(2-Methoxyphenyl)Morpholine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value in the research and development of novel active pharmaceutical ingredients (APIs), particularly in the central nervous system (CNS) and other therapeutic areas. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in asymmetric synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a building block in catalytic and stoichiometric asymmetric reactions to introduce the (R)-configured morpholine moiety.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Development: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(3R)-3-(2-Methoxyphenyl)Morpholine Hydrochloride
CAS No.	1391400-34-2
Molecular Formula	C11H15NO2 • HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	(R)-3-(2-Methoxyphenyl)morpholine hydrochloride; (3R)-3-(2-Methoxyphenyl)morpholine HCl; (R)-3-(o-Methoxyphenyl)morpholine hydrochloride; 2-Methoxy-(R)-phenylmorpholine hydrochloride; (R)-2-Methoxyphenylmorpholine HCl; (R)-3-(2-Methoxyphenyl)-3,4-dihydro-2H-1,4-oxazine hydrochloride; (R)-3-(2-Methoxyphenyl)morpholinium chloride
EINECS	Contact for details

Quality Control

Our (3R)-3-(2-Methoxyphenyl)Morpholine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.