Description

tert-Butyl n-[1-(Pyrazin-2-Yl)Azetidin-3-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a unique heterocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The azetidine-pyrazine core structure is valuable for creating inhibitors of various enzymes, including kinases and proteases.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring high-fidelity chiral intermediates.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl n-[1-(Pyrazin-2-Yl)Azetidin-3-Yl]Carbamate
CAS No.	1389313-26-1
Molecular Formula	C12H18N4O2
Molecular Weight	250.30 g/mol
Synonyms	tert-Butyl (1-(pyrazin-2-yl)azetidin-3-yl)carbamate; 1-Boc-3-amino-1-(pyrazin-2-yl)azetidine; 3-[(tert-Butoxycarbonyl)amino]-1-(2-pyrazinyl)azetidine; 1-(Pyrazin-2-yl)azetidin-3-amine, N-Boc-protected; Boc-Azetidine-Pyrazine Intermediate; BOC-1-(2-Pyrazinyl)-3-azetidinamine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[1-(Pyrazin-2-Yl)Azetidin-3-Yl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, supporting our commitment to supplying reliable intermediates for critical pharmaceutical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.