Description

(R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)-5-Oxopiperazine-1-Carboxylate is a high-purity chiral piperazine derivative serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and other therapeutic areas. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of proprietary drug candidates, especially those targeting specific biological pathways.
• API Development: Used in research and process development for constructing the core scaffold of potential new chemical entities (NCEs).
• Asymmetric Synthesis: Leverages its defined (R)-configuration for introducing stereochemical complexity in medicinal chemistry programs.
• Preclinical & Clinical Trial Material: Supplied under controlled conditions for the production of batches intended for non-clinical and clinical studies.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing.
• Chemical Biology Research: Serves as a tool compound or precursor for probing enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	(R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)-5-Oxopiperazine-1-Carboxylate
CAS No.	1384268-90-9
Molecular Formula	C17H24N2O4
Molecular Weight	320.39 g/mol
Synonyms	1-Boc-4-benzyl-3-(hydroxymethyl)piperazin-2-one (R-enantiomer); (R)-1-(tert-Butoxycarbonyl)-4-benzyl-3-(hydroxymethyl)-2-piperazinone; tert-Butyl (R)-4-benzyl-3-(hydroxymethyl)-5-oxopiperazine-1-carboxylate; (R)-1-Boc-4-benzyl-3-(hydroxymethyl)piperazin-2-one; (R)-Boc-4-Bn-3-(hydroxymethyl)-2-piperazinone; (R)-N-Boc-4-benzyl-3-(hydroxymethyl)-2-piperazinone; (R)-4-Benzyl-3-(hydroxymethyl)-1-Boc-piperazin-2-one
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 4-Benzyl-3-(Hydroxymethyl)-5-Oxopiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.