Description

(R)-1-tert-Butyl 3-Ethyl 4-Benzyl-5-Oxopiperazine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its chiral piperazine-dione core structure. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. Pharmaceutical R&D departments and fine chemical manufacturers need this material for developing novel therapeutic agents and for process optimization in regulated synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial production of proprietary drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and synthesis of peptidomimetics and protease inhibitors.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-compliant API production under strict quality agreements.
• Academic & Industrial R&D: Used in medicinal chemistry programs for lead optimization and structure-activity relationship (SAR) studies.
• Precursor to Biologically Active Molecules: An essential precursor in multi-step syntheses targeting molecules with potential receptor binding or enzyme inhibitory activity.

Basic Information

Product Name	(R)-1-tert-Butyl 3-Ethyl 4-Benzyl-5-Oxopiperazine-1,3-Dicarboxylate
CAS No.	1384268-70-5
Molecular Formula	C19H26N2O5
Molecular Weight	362.42 g/mol
Synonyms	1-(1,1-Dimethylethyl) 3-ethyl (3R)-4-(phenylmethyl)-2,5-dioxo-1-piperazinecarboxylate; (3R)-1-tert-Butyl 3-ethyl 4-benzyl-2,5-dioxopiperazine-1,3-dicarboxylate; 1-Boc-3-Ethyl (R)-4-Benzyl-2,5-dioxopiperazine-1,3-dicarboxylate; (R)-1-Boc-3-Ethyl 4-benzyl-5-oxopiperazine-1,3-dicarboxylate; tert-Butyl (3R)-3-[(ethoxycarbonyl)amino]-4-(phenylmethyl)-2,5-dioxo-1-piperazinecarboxylate; (R)-4-Benzyl-1-Boc-3-ethyl 2,5-dioxopiperazine-1,3-dicarboxylate; 1384268-70-5; (R)-N-Boc-N'-Ethyl-4-benzyl-2,5-dioxopiperazine-1,3-dicarboxylate
EINECS	Contact for details

Quality Control

Our (R)-1-tert-Butyl 3-Ethyl 4-Benzyl-5-Oxopiperazine-1,3-Dicarboxylate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Certificates of Analysis (COA) are provided with each shipment, detailing results from HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry analyses. We support development and commercial projects requiring compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.