Description

m-Peg10-Amine is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a terminal primary amine group, essential for bioconjugation and linker chemistry. This compound matters for its role as a versatile heterobifunctional crosslinker, enabling the stable attachment of biomolecules, drugs, or probes while imparting beneficial solubility and stealth properties. Pharmaceutical researchers, biotech developers, and advanced material scientists need it for creating PEGylated therapeutics, diagnostic agents, and functionalized nanoparticles. Its defined 10-unit PEG spacer offers optimal length for modifying pharmacokinetics and reducing immunogenicity.

Application

• Bioconjugation & Drug Delivery: A key reagent for site-specific PEGylation of peptides, proteins, antibodies, and oligonucleotides to enhance stability and circulation half-life.
• Linker for ADC Development: Used in Antibody-Drug Conjugate (ADC) payload attachment strategies, providing a cleavable or non-cleavable spacer between the antibody and cytotoxic agent.
• Surface Functionalization: For amine-terminated self-assembled monolayers (SAMs) on gold or silica surfaces, creating bio-inert or reactive platforms for biosensors and implants.
• Nanoparticle & Liposome Modification: Conjugation to lipids or polymer backbones to create stealth nanoparticles with reduced protein opsonization for targeted delivery.
• Hydrogel & Biomaterial Synthesis: Acts as a crosslinking agent or functional monomer in the preparation of biocompatible hydrogels and scaffolds for tissue engineering.
• Diagnostic Probe Synthesis: Facilitates the labeling of targeting molecules (e.g., antibodies, aptamers) with fluorescent dyes, MRI contrast agents, or radionuclides.

Basic Information

Product Name	m-Peg10-Amine
CAS No.	1383658-09-0
Molecular Formula	C23H47NO11
Molecular Weight	513.6 g/mol
Synonyms	mPEG10-NH2; Amino-PEG10-alcohol; 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-amine; α-Methyl-ω-amino-poly(ethylene glycol), MW ~500; Monomethoxy PEG Amine (n=10); O-(2-Aminoethyl)-O'-methyl-decaethylene glycol; PEG10 Methyl Ether Amine; Amine-PEG10-OMe
EINECS	Contact for details

Quality Control

Our m-Peg10-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for molecular weight verification. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, supporting compliance with cGMP and ISO 9001 standards where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, recommended storage temperature is -20°C to -10°C. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 90.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	513.6 ± 5
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.