Description

Pyrazino[2,1-C][1,4]Oxazin-4(3H)-One, Hexahydro-, Hydrochloride (1:1), (9Ar)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Integrated into the production process of complex Active Pharmaceutical Ingredients (APIs), especially those containing fused polycyclic systems.
• Bioconjugation & Probe Development: Potential utility in creating chemical probes or conjugates for biochemical and pharmacological research due to its reactive functional groups.
• Process Chemistry & Scale-Up: Supplied for route scouting, process development, and cGMP manufacturing of clinical trial materials.

Basic Information

Product Name	Pyrazino[2,1-C][1,4]Oxazin-4(3H)-One, Hexahydro-, Hydrochloride (1:1), (9Ar)-
CAS No.	1383427-89-1
Molecular Formula	C7H11N3O2 • HCl
Molecular Weight	205.64 g/mol (Free base: 169.18 g/mol)
Synonyms	(9aR)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride; Hexahydro-3H-pyrazino[2,1-c][1,4]oxazin-4-one hydrochloride (9aR)-; (R)-Hexahydropyrazino[2,1-c][1,4]oxazin-4(3H)-one hydrochloride; 1383427-89-1; UNII-8K3J5F2Q6F; SCHEMBL21824027; AKOS040757623; (R)-1,2,3,6,7,8-Hexahydro-4H-pyrazino[2,1-c][1,4]oxazin-4-one hydrochloride
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC/GC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.