Description

(R)-1-Boc-2-tert-Butyl-Piperazine is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs), enabling precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutics, particularly in areas requiring complex, nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) research.
• Asymmetric Catalyst Ligand Precursor: Used in the development of chiral ligands for asymmetric catalysis, enhancing enantioselectivity in critical bond-forming reactions.
• Peptidomimetic Chemistry: Incorporated into the backbone of peptidomimetics to improve metabolic stability and bioavailability of peptide-based drug leads.
• Agrochemical Research: Serves as a structural component in the synthesis of advanced, chiral agrochemicals with specific biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(R)-1-Boc-2-tert-Butyl-Piperazine
CAS No.	1382035-40-6
Molecular Formula	C13H26N2O2
Molecular Weight	242.36 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-tert-butylpiperazine; (R)-2-tert-Butyl-1-Boc-piperazine; (R)-N-Boc-2-tert-butylpiperazine; tert-Butyl (R)-2-tert-butylpiperazine-1-carboxylate; (R)-1-Boc-2-t-butylpiperazine; (R)-1-Boc-2-tert-butylpiperazine; (R)-2-tert-Butyl-1-(tert-butoxycarbonyl)piperazine; (R)-1,2-Di-tert-butylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-tert-Butyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.