Description

(S)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hydrochloride is a high-purity, chiral piperazine derivative used as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in creating novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• API Development: Used in constructing the core piperazine moiety for potential APIs requiring specific (S)-configuration.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations and chiral pool synthesis.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a versatile, protected piperazine building block.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of chiral pharmaceuticals.
• Chemical Biology & Proteomics: Can be utilized for designing enzyme inhibitors or molecular probes targeting specific biological pathways.

Basic Information

Product Name	(S)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1381959-73-4
Molecular Formula	C13H27N2O2 • HCl
Molecular Weight	278.83 g/mol (Free base: 243.37 g/mol)
Synonyms	1-Boc-2-tert-butyl-(S)-piperazine hydrochloride; (S)-1-(tert-Butoxycarbonyl)-2-tert-butylpiperazine hydrochloride; (S)-1-Boc-2-tert-butylpiperazine HCl; (S)-N-Boc-2-tert-butylpiperazine hydrochloride; tert-Butyl (S)-2-(tert-butyl)piperazine-1-carboxylate hydrochloride; (S)-2-tert-Butyl-1-Boc-piperazine hydrochloride; (S)-1,2-Di-tert-butylpiperazine-1-carboxylate hydrochloride; (S)-Boc-2-t-butylpiperazine HCl
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (ee), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.