Description

(R)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hcl is a high-purity, chiral piperazine derivative and a crucial building block in modern pharmaceutical synthesis. This compound matters because it provides a structurally defined, enantiomerically pure scaffold essential for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. Pharmaceutical R&D and fine chemical manufacturers need it for the synthesis of complex drug candidates, particularly in therapeutic areas targeting the central nervous system and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a ligand or organocatalyst precursor in stereoselective chemical transformations.
• Medicinal Chemistry: Serves as a core structural motif for constructing compound libraries in drug discovery programs.
• Peptidomimetics: Incorporated into the design of peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	(R)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hydrochloride
CAS No.	1381958-53-7
Molecular Formula	C13H27N2O2 • HCl
Molecular Weight	278.83 g/mol (Free base: 241.36 g/mol)
Synonyms	1-Boc-2-tert-butyl-(R)-piperazine hydrochloride; (R)-1-Boc-2-tert-butylpiperazine HCl; tert-Butyl (R)-2-(tert-butyl)piperazine-1-carboxylate hydrochloride; (R)-1-(tert-Butoxycarbonyl)-2-tert-butylpiperazine hydrochloride; (R)-N-Boc-2-tert-butylpiperazine HCl; (R)-2-tert-Butyl-1-Boc-piperazine hydrochloride; BOC-(R)-2-tert-butylpiperazine HCl; (R)-2-tert-Butylpiperazine-1-carboxylic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-tert-Butylpiperazine-1-Carboxylate Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.