Description

1-Boc-2-tert-Butylpiperazine Hydrochloride is a high-purity, protected piperazine derivative essential for advanced organic synthesis. This compound serves as a critical building block in pharmaceutical research and development, enabling the controlled introduction of the piperazine scaffold. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in parallel and combinatorial synthesis for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and constructing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring high-purity, functionalized heterocycles.

Basic Information

Product Name	1-Boc-2-tert-Butylpiperazine Hydrochloride
CAS No.	1381947-73-4
Molecular Formula	C13H27ClN2O2
Molecular Weight	278.82 g/mol
Synonyms	1-Boc-2-tert-butylpiperazine HCl; tert-Butyl 2-(tert-butyl)piperazine-1-carboxylate hydrochloride; 2-tert-Butyl-1-(tert-butoxycarbonyl)piperazine hydrochloride; 1-(tert-Butoxycarbonyl)-2-tert-butylpiperazine hydrochloride; 1-Boc-2-t-butylpiperazine hydrochloride; Piperazine, 2-(1,1-dimethylethyl)-1-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1); BOC-2-T-BUTYL-PIPERAZINE HCL
EINECS	Contact for details

Quality Control

Our 1-Boc-2-tert-Butylpiperazine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.