Description

Hydroxy-Peg3-Ethyl Ester CAS NO 1379649-80-5 is a high-purity polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and an ethyl ester, designed as a versatile bifunctional linker and building block. Its precise molecular structure provides controlled hydrophilicity and reactivity, making it essential for modifying the physicochemical properties of target molecules. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing prodrugs, polymer conjugates, and functionalized surfaces.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, enabling controlled drug release.
• Prodrug Development: Used to create water-soluble prodrugs by conjugating active pharmaceutical ingredients (APIs) to the PEG chain, improving bioavailability.
• Polymer Chemistry: Serves as a monomer or functional initiator/terminator in the synthesis of tailored, biocompatible PEG-based copolymers and hydrogels.
• Surface Modification: Employed to functionalize nanoparticles, diagnostic agents, and medical device surfaces to enhance biocompatibility and reduce immunogenicity.
• Cross-linking Agent: Acts as a hydrophilic spacer in cross-linking reactions for creating three-dimensional polymer networks with specific mesh sizes.
• Chemical Biology Tool: Used in proteomics and bioconjugation research to introduce PEG chains onto proteins, peptides, or small molecules for stability and solubility studies.

Basic Information

Product Name	Hydroxy-Peg3-Ethyl Ester
CAS No.	1379649-80-5
Molecular Formula	C11H22O6
Molecular Weight	250.29 g/mol
Synonyms	3,6,9-Trioxaundecanedioic acid, 11-hydroxy-, 1-ethyl ester; 11-Hydroxy-3,6,9-trioxaundecanoic acid ethyl ester; Ethyl 11-hydroxy-3,6,9-trioxaundecanoate; HO-PEG3-CH2CH2COOEt; 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl propionate; PEG3 ethyl ester alcohol; Hydroxy-PEG3-ethyl ester; Hydroxy-PEG3-C2-acid ethyl ester
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.