Description

tert-Butyl (7S,8As)-7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound is crucial for the development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of complex molecules with specific stereochemical configurations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry for therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those containing fused pyrrolo-pyrazine ring systems.
• Peptidomimetic Research: Serves as a constrained scaffold for designing and synthesizing peptidomimetics and macrocyclic compounds in medicinal chemistry.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric transformations to introduce stereocenters in target molecules.
• API Development: Critical for the research, development, and scale-up of new Active Pharmaceutical Ingredients (APIs) requiring this specific bicyclic structure.
• Process Chemistry & Optimization: Employed in route scouting and process development for the efficient, scalable manufacturing of target compounds.
• Chemical Biology Probes: Can be utilized to create specialized molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl (7S,8As)-7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate
CAS No.	1378368-35-4
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	(7S,8aS)-tert-Butyl 7-hydroxyhexahydro-1H-pyrrolo[1,2-a]pyrazine-2(6H)-carboxylate; (7S,8aS)-2-(tert-Butoxycarbonyl)-7-hydroxyhexahydro-1H-pyrrolo[1,2-a]pyrazine; tert-Butyl (7S,8aS)-7-hydroxyoctahydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylate; BOC-Protected Hydroxy Pyrrolopyrazine; (7S,8aS)-Boc-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine; Chiral Pyrrolopyrazine Building Block; 1378368-35-4
EINECS	Contact for details

Quality Control

Our tert-Butyl (7S,8As)-7-Hydroxyhexahydropyrrolo[1,2-A]Pyrazine-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.