Description

tert-Butyl 3-(Aminomethyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its bifunctional nature, featuring both a Boc-protected secondary amine and a primary aminomethyl group, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in oncology and CNS research.
• Building Block for PROTACs: Used to construct linker components in Proteolysis Targeting Chimeras (PROTACs) due to its dual functional handles.
• Agrochemical Synthesis: Serves as a precursor for developing new fungicides and herbicides with enhanced activity.
• Peptidomimetic Chemistry: Incorporated into peptide backbones to modulate stability, bioavailability, and receptor binding.
• Ligand Synthesis for Catalysis: Used to prepare chelating ligands for transition metal catalysts.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)Piperazine-1-Carboxylate
CAS No.	1376099-80-7
Molecular Formula	C10H21N3O2
Molecular Weight	215.29 g/mol
Synonyms	1-Boc-3-(aminomethyl)piperazine; tert-Butyl 3-(aminomethyl)-1-piperazinecarboxylate; 3-(Aminomethyl)-N-Boc-piperazine; 1-Piperazinecarboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester; 1-N-Boc-3-(aminomethyl)piperazine; Boc-3-(aminomethyl)piperazine; 3-Aminomethyl-1-Boc-piperazine; 1376099-80-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Aminomethyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.