Description

Methyl 6-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylate is a high-purity, protected piperazine-pyrazine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the synthesis of targeted therapeutics. The Boc-protected piperazine moiety offers strategic advantages for selective deprotection and further functionalization in multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies for novel therapeutic agents.
• Process Chemistry & Scale-up: Serves as a defined starting material or intermediate in the development and optimization of commercial-scale API manufacturing processes.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and advanced intermediates for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and peptide-mimetic chemistry.

Basic Information

Product Name	Methyl 6-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylate
CAS No.	1375702-27-4
Molecular Formula	C15H22N4O4
Molecular Weight	322.36 g/mol
Synonyms	Methyl 6-(4-Boc-piperazin-1-yl)pyrazine-2-carboxylate; 6-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid methyl ester; 1-Boc-4-(6-(methoxycarbonyl)pyrazin-2-yl)piperazine; tert-Butyl 4-(6-(methoxycarbonyl)pyrazin-2-yl)piperazine-1-carboxylate; Methyl 6-(1-Boc-4-piperazinyl)-2-pyrazinecarboxylate; Boc-Pip-Pyz-COOMe (abbrev.); CAS 1375702-27-4
EINECS	Contact for details

Quality Control

Our Methyl 6-(4-(tert-Butoxycarbonyl)Piperazin-1-Yl)Pyrazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP (current Good Manufacturing Practice) requirements for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.