Description

Tak875 is a high-purity, non-peptidic GPR40 agonist, identified by the CAS registry number 1374598-80-7. This compound is of significant interest for its role as a potent and selective agonist of the G-protein-coupled receptor 40 (GPR40), which is a key target in metabolic disorder research. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) engaged in the discovery and development of novel therapeutics for type 2 diabetes and related metabolic syndromes.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel GPR40-targeting therapies.
• Metabolic Disease Studies: Used as a pharmacological tool compound in in vitro and in vivo studies to investigate insulin secretion mechanisms and pancreatic β-cell function.
• High-Throughput Screening (HTS): Employed as a positive control in assay development and screening campaigns to identify new GPR40 modulators.
• Preclinical Development: Integral to pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies for candidate drug molecules.
• Academic Research: Utilized in university and institutional labs for fundamental research into GPCR signaling pathways and diabetes pathophysiology.
• Biochemical Assays: Acts as a ligand in binding assays (e.g., fluorescence polarization, scintillation proximity) to characterize receptor-ligand interactions.

Basic Information

Product Name	Tak875
CAS No.	1374598-80-7
Molecular Formula	C29H28F3NO5S
Molecular Weight	559.60 g/mol
Synonyms	Fasiglifam; TAK-875; GPR40 Agonist TAK-875; (3S)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-carboxylic Acid; GPR40/FFAR1 Agonist
EINECS	Contact for details

Quality Control

Our Tak875 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.