Description

2-Ethynyl-5-Methoxypyrazine is a high-purity, specialized heterocyclic building block featuring both an ethynyl and a methoxy substituent on the pyrazine core. This compound is valued for its unique reactivity profile, serving as a key intermediate in the synthesis of complex molecules for advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and flavor & fragrance industries for creating novel active ingredients and aroma compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic disorders.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Flavor & Fragrance Ingredient: Serves as a precursor for synthesizing high-value pyrazine derivatives that impart roasted, nutty, or green sensory notes.
• Material Science Research: Employed as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Chemical Synthesis Reagent: Acts as a versatile synthon in organic chemistry for coupling reactions (e.g., Sonogashira, Click Chemistry) due to the reactive ethynyl group.

Basic Information

Product Name	2-Ethynyl-5-Methoxypyrazine
CAS No.	1374115-62-4
Molecular Formula	C7H6N2O
Molecular Weight	134.14 g/mol
Synonyms	5-Methoxy-2-ethynylpyrazine; 2-Ethynyl-5-methoxypyrazine; 2-Methoxy-5-ethynylpyrazine; 5-Methoxy-2-ethinylpyrazin; Ethynylmethoxypyrazine; Pyrazine, 2-ethynyl-5-methoxy-; (5-Methoxypyrazin-2-yl)acetylene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-5-Methoxypyrazine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and process development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.