Description

2-Chloro-3-Ethynylpyrazine is a high-purity, functionalized pyrazine derivative characterized by its reactive ethynyl and chloro substituents. This compound serves as a versatile and critical pharmaceutical intermediate and organic building block for advanced synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probe: Employed in click chemistry and bioconjugation strategies for labeling and studying biological systems.
• Ligand Synthesis: Useful for constructing complex heterocyclic ligands for catalysis and coordination chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Chloro-3-Ethynylpyrazine
CAS No.	1374115-59-9
Molecular Formula	C6H3ClN2
Molecular Weight	138.55 g/mol
Synonyms	3-Ethynyl-2-chloropyrazine; 2-Chloro-3-ethynylpyrazine; 2-Chloro-3-ethynyl-pyrazine; Pyrazine, 2-chloro-3-ethynyl-; 1374115-59-9
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Ethynylpyrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, GC for residual solvents, and 1H/13C NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.