Description

8-Arm Peg-Sh CAS NO 1373957-75-5 is a multi-arm, heterobifunctional polyethylene glycol derivative featuring a thiol (-SH) group for conjugation. This branched architecture provides a high-density, multi-valent platform for creating complex biomolecular constructs and advanced materials. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced material science sectors who require precise, multi-point functionalization to enhance stability, solubility, and payload capacity.

Application

• Bioconjugation and Linker Chemistry: Serves as a multi-valent linker for attaching peptides, proteins, oligonucleotides, or drugs to surfaces, nanoparticles, or other polymers via the thiol group.
• Hydrogel Formation: Used as a cross-linking agent to create PEG-based hydrogels with tunable mechanical properties for tissue engineering and drug delivery matrices.
• Drug Delivery Systems: Facilitates the development of multi-arm PEG-drug conjugates (prodrugs) to improve pharmacokinetics, solubility, and targeted release.
• Surface Functionalization: Enables the creation of dense, brush-like PEG layers on biosensor surfaces or medical devices to confer anti-fouling properties.
• Diagnostic Reagents: Acts as a scaffold for assembling multi-epitope diagnostic probes or contrast agents for enhanced signal detection.
• Protein and Antibody Modification: Used for site-specific PEGylation to create multi-PEGylated proteins, potentially reducing immunogenicity and increasing circulatory half-life.

Basic Information

Item	Detail
Product Name	8-Arm Peg-Sh
CAS No.	1373957-75-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details (Grade Dependent)
Synonyms	Octa-Arm PEG Thiol; 8-Arm Polyethylene Glycol Thiol; 8-Arm PEG-SH; Multi-Arm PEG Thiol; Octafunctional PEG Thiol; Star PEG Thiol; 8-Arm PEG Terminated with Thiol; Heterobifunctional 8-Arm PEG
EINECS	Contact for details

Quality Control

Our 8-Arm Peg-Sh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing specifications such as molecular weight distribution (by GPC), degree of substitution, thiol content, and purity (by HPLC) are provided to guarantee consistent performance for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Complies
Assay (Thiol Content)	> 95%
Purity (HPLC)	> 98%
Molecular Weight (GPC)	As per ordered grade (e.g., 10kDa, 20kDa, 40kDa)
Polydispersity Index (PDI)	≤ 1.05
Moisture Content (KF)	< 1.0%
Solubility	Soluble in water, DMSO, DMF, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.