Description

tert-Butyl 3,3-Difluoro-4-Methylenepiperidine-1-Carboxylate is a high-value, fluorinated piperidine derivative serving as a critical synthetic intermediate. This compound is essential for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers seeking to incorporate advanced fluorinated building blocks into their molecular libraries.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, leveraging the unique properties of fluorine to modulate bioavailability, metabolic stability, and binding affinity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, particularly in central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Serves as a precursor for developing advanced, fluorinated active ingredients in crop protection products, where fluorine atoms can enhance efficacy and environmental profile.
• Fluorine Chemistry Library: An important component for chemical libraries focused on fluorine-containing compounds, supporting drug discovery and material science innovation.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the custom production of complex molecules for client projects.

Basic Information

Product Name	tert-Butyl 3,3-Difluoro-4-Methylenepiperidine-1-Carboxylate
CAS No.	1373503-15-1
Molecular Formula	C12H19F2NO2
Molecular Weight	247.28 g/mol
Synonyms	1-Boc-3,3-difluoro-4-methylenepiperidine; 1-(tert-Butoxycarbonyl)-3,3-difluoro-4-methylenepiperidine; 4-Methylene-3,3-difluoropiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3,3-difluoro-4-methylidenepiperidine-1-carboxylate; 3,3-Difluoro-4-methylenepiperidine-1-carboxylic acid tert-butyl ester; Boc-3,3-difluoro-4-methylenepiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoro-4-Methylenepiperidine-1-Carboxylate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full specification data are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.