Description

(R)-1,3-Dimethyl-Piperazin-2-One Hydrochloride is a high-purity chiral piperazinone derivative, a crucial building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for developing active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors focused on innovative drug development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and antiviral targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the research and scale-up of new therapeutic candidates.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for novel bioactive compounds.
• Process Chemistry & Scale-Up: Used in the development of robust, scalable synthetic routes for commercial pharmaceutical manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(R)-1,3-Dimethyl-Piperazin-2-One Hydrochloride
CAS No.	1373232-29-1
Molecular Formula	C7H15ClN2O
Molecular Weight	178.66 g/mol
Synonyms	(R)-1,3-Dimethyl-2-oxopiperazinium chloride; (R)-1,3-Dimethylpiperazin-2-one hydrochloride; (R)-3,5-Dimethyl-2-oxopiperazin-1-ium chloride; (R)-1,3-Dimethylpiperazine-2-one HCl; (R)-1,3-Dimethyl-2-piperazinone hydrochloride; (R)-enantiomer of 1,3-Dimethylpiperazin-2-one hydrochloride; UNII-7J2S5I8K1T (FDA UNII Code)
EINECS	Contact for details

Quality Control

Our (R)-1,3-Dimethyl-Piperazin-2-One Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for advanced research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), chiral purity (typically ≥99% ee), and impurity profiles. We adhere to ICH guidelines for analytical method validation where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.