Description

6-(Trifluoromethyl)Imidazo[1,2-A]Pyrazine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a fused imidazopyrazine heterocycle with a carboxylic acid handle and a trifluoromethyl group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drugs targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the imidazopyrazine scaffold.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Material Science: Potential building block for the synthesis of specialty polymers, ligands, or organic electronic materials due to its unique heterocyclic structure.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process optimization for client projects.

Basic Information

Product Name	6-(Trifluoromethyl)Imidazo[1,2-A]Pyrazine-2-Carboxylic Acid
CAS No.	1372197-49-3
Molecular Formula	C8H4F3N3O2
Molecular Weight	231.13 g/mol
Synonyms	6-(Trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid; Imidazo[1,2-a]pyrazine-2-carboxylic acid, 6-(trifluoromethyl)-; 1372197-49-3; 6-Trifluoromethylimidazo[1,2-a]pyrazine-2-carboxylic Acid; 6-(Trifluoromethyl)-2-imidazo[1,2-a]pyrazinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Imidazo[1,2-A]Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.