Description

2-Ethynyl-3-Fluoro-5-Methylpyridine is a high-value, multi-functional pyridine derivative featuring a reactive ethynyl group and a fluorine substituent. This compound is a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex molecules. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its fluorine and pyridine motifs.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Ligand Synthesis: Employed in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry programs focused on creating fluorinated compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	2-Ethynyl-3-Fluoro-5-Methylpyridine
CAS No.	1372103-91-7
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	3-Fluoro-5-methyl-2-ethynylpyridine; 2-Ethynyl-3-fluoro-5-picoline; 5-Methyl-3-fluoro-2-ethynylpyridine; 2-Ethynyl-3-fluoro-5-methyl-pyridine; Pyridine, 2-ethynyl-3-fluoro-5-methyl-; (3-Fluoro-5-methylpyridin-2-yl)acetylene
EINECS	Contact for details

Quality Control

Every batch of 2-Ethynyl-3-Fluoro-5-Methylpyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Due to its highly volatile nature, ensure containers are kept tightly sealed and at a consistent temperature, ideally between 2°C and 8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.