Description

1-(Oxetan-3-Yl)Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1369338-92-0. This heterocyclic building block is valued for its unique oxetane-piperazine scaffold, which is critical for modulating the physicochemical and pharmacokinetic properties of novel drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of innovative therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new chemical entities (NCEs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used to introduce the oxetane moiety, which can improve metabolic stability, solubility, and membrane permeability of lead compounds.
• Process Chemistry & Scale-up: Serves as a critical raw material for process development and the cGMP manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation & Linker Chemistry: The piperazine nitrogen can be utilized for conjugation in the development of antibody-drug conjugates (ADCs) or PROTACs.
• Agrochemical Research: Potential intermediate in the discovery of new crop protection agents with enhanced activity profiles.

Basic Information

Product Name	1-(Oxetan-3-Yl)Piperazine Hydrochloride
CAS No.	1369338-92-0
Molecular Formula	C7H15ClN2O
Molecular Weight	178.66 g/mol
Synonyms	1-(Oxetan-3-yl)piperazine hydrochloride; 3-Piperazin-1-yloxetane hydrochloride; Oxetan-3-yl-piperazine HCl; Piperazine, 1-(oxetan-3-yl)-, hydrochloride; 1-(Oxetane-3-yl)piperazine hydrochloride; 1369338-92-0; UNII-6H9V3C6U4P
EINECS	Contact for details

Quality Control

Our 1-(Oxetan-3-Yl)Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.