Description

1-(3-Chloro-5-Nitropyridin-2-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine-piperazine scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the scaled-up production of specific APIs requiring this precise molecular framework.
• Contract Research Organizations (CROs): Supplied to CROs for client-sponsored drug discovery and development projects.

Basic Information

Product Name	1-(3-Chloro-5-Nitropyridin-2-Yl)Piperazine
CAS No.	1368438-85-0
Molecular Formula	C9H11ClN4O2
Molecular Weight	242.66 g/mol
Synonyms	1-(3-Chloro-5-nitropyridin-2-yl)piperazine; 2-Piperazino-3-chloro-5-nitropyridine; 3-Chloro-5-nitro-2-piperazinopyridine; 1-(3-Chloro-5-nitro-2-pyridinyl)piperazine; 1368438-85-0; 3-Chloro-5-nitropyridin-2-yl piperazine; 2-(Piperazin-1-yl)-3-chloro-5-nitropyridine
EINECS	Contact for details

Quality Control

Our 1-(3-Chloro-5-Nitropyridin-2-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.