Description

6-(tert-Butyl)-4-Hydroxynicotinic Acid CAS NO 1367828-93-0 is a high-purity, functionalized nicotinic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a sterically hindered tert-butyl group and a phenolic hydroxyl on the pyridine ring, makes it a versatile intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and fine-tune material characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and plant growth regulators with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used to create chelating ligands for metal catalysts in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing functional polymers, coordination complexes, and organic electronic materials.
• Chemical Biology Probes: Serves as a core structure for designing enzyme inhibitors and molecular probes for biological research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical development projects.

Basic Information

Product Name	6-(tert-Butyl)-4-Hydroxynicotinic Acid
CAS No.	1367828-93-0
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	4-Hydroxy-6-tert-butylnicotinic acid; 6-tert-Butyl-4-hydroxypyridine-3-carboxylic acid; 4-Hydroxy-6-(1,1-dimethylethyl)-3-pyridinecarboxylic acid; 3-Pyridinecarboxylic acid, 4-hydroxy-6-(1,1-dimethylethyl)-; 6-tert-Butyl-4-hydroxynicotinate (acid form); 6-(tert-Butyl)-4-hydroxynicotinic acid; 4-Hydroxy-6-(tert-butyl)nicotinic acid
EINECS	Contact for details

Quality Control

Our 6-(tert-Butyl)-4-Hydroxynicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity intermediates for regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to strong light should be avoided. Keep the container sealed to minimize contact with moisture and atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.