Description

Fmoc-(S)-Thiazolidine-2-Carboxylic Acid CAS NO 1366384-03-3 is a high-purity, chiral amino acid derivative where the amine group is protected by a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Pharmaceutical Intermediates: Serves as a key chiral precursor in the research and development of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Used to incorporate the thiazolidine moiety into peptides for creating fluorescent probes, affinity tags, or drug conjugates.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions, enzyme mechanisms, and cellular processes using synthetic peptides.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-(S)-Thiazolidine-2-Carboxylic Acid
CAS No.	1366384-03-3
Molecular Formula	C19H17NO4S
Molecular Weight	355.41 g/mol
Synonyms	Fmoc-Thz-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-thiazolidine-2-carboxylic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)thiazolidine-2-carboxylic acid; Fmoc-L-thiazolidine-2-carboxylic acid; Fmoc-(S)-2-thiazolidinecarboxylic acid; N-Fmoc-L-thiazolidine-2-carboxylic acid; L-Thiazolidine-2-carboxylic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-Thiazolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.