Description

tert-Butyl n-{[1-(Pyrimidin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine-pyrimidine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates, particularly in areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing complex molecular scaffolds with potential biological activity.
• Protease Inhibitor Development: Serves as a precursor in the design and synthesis of protease inhibitors due to its piperidine-pyrimidine structure.
• Kinase Inhibitor Synthesis: Employed in the creation of potential kinase inhibitor candidates for oncology and inflammatory disease research.
• Chemical Biology Probes: Utilized for developing molecular probes to study enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl n-{[1-(Pyrimidin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate
CAS No.	1365988-45-9
Molecular Formula	C15H24N4O2
Molecular Weight	292.38 g/mol
Synonyms	Boc-4-(aminomethyl)-1-(pyrimidin-2-yl)piperidine; 1-(Pyrimidin-2-yl)piperidine-4-methanamine, N-Boc-protected; tert-Butyl [1-(2-pyrimidinyl)-4-piperidinylmethyl]carbamate; 1-Boc-4-(aminomethyl)-1-(pyrimidin-2-yl)piperidine; 4-[(tert-Butoxycarbonylamino)methyl]-1-(pyrimidin-2-yl)piperidine; N-Boc-1-(2-Pyrimidinyl)-4-piperidinemethanamine; 1365988-45-9; tert-Butyl N-[[1-(pyrimidin-2-yl)piperidin-4-yl]methyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-{[1-(Pyrimidin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.