Description

2-Bromo-3-(Trifluoromethyl)Pyrazine is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing both halogen and fluorine motifs into molecular scaffolds, enabling the fine-tuning of physicochemical properties in advanced materials and active ingredients. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds with enhanced bioactivity, stability, and performance.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Material Science: Serves as a precursor for functionalized pyrazine derivatives used in electronic materials, liquid crystals, and organic semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry: The -CF3 group provides a stable source of fluorine for modulating polarity, metabolic resistance, and binding affinity in drug discovery.
• Chemical Synthesis: Employed in academic and industrial R&D for the construction of diverse heterocyclic libraries for screening and lead optimization.

Basic Information

Product Name	2-Bromo-3-(Trifluoromethyl)Pyrazine
CAS No.	1365988-38-0
Molecular Formula	C5H2BrF3N2
Molecular Weight	226.98 g/mol
Synonyms	2-Bromo-3-(trifluoromethyl)pyrazine; 3-Bromo-2-(trifluoromethyl)pyrazine; Pyrazine, 2-bromo-3-(trifluoromethyl)-; 2-(Trifluoromethyl)-3-bromopyrazine; 1365988-38-0; 2-Bromo-3-trifluoromethylpyrazine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-(Trifluoromethyl)Pyrazine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.