Description

tert-Butyl n-{[1-(Pyrazin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate CAS NO 1365968-55-3 is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core linked to a pyrazine moiety and protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for CNS-targeting drugs.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable piperidine-pyrazine scaffold.
• Protease Inhibitor Synthesis: Serves as a core structure in the development of protease inhibitors for various therapeutic applications.
• Kinase Inhibitor Research: Employed in the synthesis of potential kinase inhibitors for oncology and anti-inflammatory drug discovery.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl n-{[1-(Pyrazin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate
CAS No.	1365968-55-3
Molecular Formula	C16H24N4O2
Molecular Weight	304.39 g/mol
Synonyms	tert-Butyl N-[(1-pyrazin-2-ylpiperidin-4-yl)methyl]carbamate; 1-Boc-4-(aminomethyl)-1-(pyrazin-2-yl)piperidine; 4-[(tert-Butoxycarbonylamino)methyl]-1-(pyrazin-2-yl)piperidine; 1-(Pyrazin-2-yl)piperidine-4-methanamine, N-Boc-protected; BOC-Pyrazinylpiperidinemethylamine; 1365968-55-3; tert-Butyl ((1-(pyrazin-2-yl)piperidin-4-yl)methyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-{[1-(Pyrazin-2-Yl)Piperidin-4-Yl]Methyl}Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and can be aligned with cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.