Description

tert-Butyl n-[(3R)-1-(Pyrazin-2-Yl)Pyrrolidin-3-Yl]Carbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates.
• API Synthesis: Used in the multi-step synthesis of complex target molecules, leveraging its protected amine and pyrazine functionalities.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for clinical trial material and commercial API manufacturing.
• Asymmetric Synthesis: Utilized in reactions where the (R)-configured pyrrolidine center is crucial for biological activity.

Basic Information

Product Name	tert-Butyl n-[(3R)-1-(Pyrazin-2-Yl)Pyrrolidin-3-Yl]Carbamate
CAS No.	1365936-73-7
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	Carbamic acid, N-[(3R)-1-(2-pyrazinyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; (R)-tert-Butyl (1-(pyrazin-2-yl)pyrrolidin-3-yl)carbamate; tert-Butyl (R)-(1-(pyrazin-2-yl)pyrrolidin-3-yl)carbamate; (R)-N-Boc-3-amino-1-(pyrazin-2-yl)pyrrolidine; BOC-(R)-3-Amino-1-(2-pyrazinyl)pyrrolidine; 1365936-73-7; (R)-1-(Pyrazin-2-yl)pyrrolidin-3-yl tert-butylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(3R)-1-(Pyrazin-2-Yl)Pyrrolidin-3-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.