Description

5-Ethynyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-value pharmaceutical intermediate and versatile building block in organic synthesis. Its core value lies in its functionalized indazole scaffold, which is integral to the development of novel bioactive compounds. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to create new molecular entities with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Sonogashira, Click chemistry) due to the reactive ethynyl group, enabling the construction of complex molecular architectures.
• Agrochemical Research: Serves as a core structure for developing new active ingredients with potential herbicidal or fungicidal activity.
• Chemical Biology Probe Development: Utilized in creating labeled compounds or affinity probes for studying biological pathways and target engagement.
• Material Science Research: Investigated as a monomer or functional additive for creating specialized polymers with unique electronic or optical properties.

Basic Information

Product Name	5-Ethynyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1365888-99-8
Molecular Formula	C14H14N2O
Molecular Weight	226.27 g/mol
Synonyms	5-Ethynyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1H-Indazole, 5-ethynyl-1-(tetrahydro-2H-pyran-2-yl)-; 5-Ethynyl-1-THP-indazole; THP-protected 5-ethynylindazole; 5-Ethynyl-1-(2-tetrahydropyranyl)-1H-indazole; 1365888-99-8; 5-Ethynylindazole THP ether
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.