Description

5-Chloro-3-(4-Chlorophenyl)-2-Fluoropyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its precise molecular architecture makes it an indispensable intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, leveraging the bioactivity of the halogenated pyridine core.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive chlorine and fluorine substituents.
• Chemical Biology Probes: Utilized in medicinal chemistry to create molecular probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated heterocycles.

Basic Information

Product Name	5-Chloro-3-(4-Chlorophenyl)-2-Fluoropyridine
CAS No.	1364677-73-5
Molecular Formula	C11H6Cl2FN
Molecular Weight	246.08 g/mol
Synonyms	2-Fluoro-5-chloro-3-(4-chlorophenyl)pyridine; 3-(4-Chlorophenyl)-5-chloro-2-fluoropyridine; 5-Chloro-3-(4-chlorophenyl)-2-fluoropyridine; 1364677-73-5; 2-Fluoro-3-(4-chlorophenyl)-5-chloropyridine; 5-Chloro-2-fluoro-3-(4-chlorophenyl)pyridine; Pyridine, 5-chloro-3-(4-chlorophenyl)-2-fluoro-
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Each batch of 5-Chloro-3-(4-Chlorophenyl)-2-Fluoropyridine is analyzed using advanced techniques like HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. Our quality system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 97.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.