Description

tert-Butyl 3-(tert-Butoxycarbonylamino)-3-cyanopyrrolidine-1-carboxylate is a high-purity, multi-protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters because it provides a versatile, stereodefined scaffold for constructing complex nitrogen-containing heterocycles, which are central to modern drug discovery. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially protease inhibitors and kinase inhibitors.
• Peptidomimetic Chemistry: Used to introduce constrained, functionalized pyrrolidine motifs that mimic peptide backbones, enhancing metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration by providing a modifiable core structure with multiple protected functional groups.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex targets for clients.
• Academic & Institutional Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	tert-Butyl 3-(tert-Butoxycarbonylamino)-3-cyanopyrrolidine-1-carboxylate
CAS No.	1364663-43-3
Molecular Formula	C15H25N3O4
Molecular Weight	311.38 g/mol
Synonyms	1,1-Dimethylethyl 3-[[(1,1-dimethylethoxy)carbonyl]amino]-3-cyano-1-pyrrolidinecarboxylate; 3-((tert-Butoxycarbonyl)amino)-3-cyanopyrrolidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-((Boc)amino)-3-cyanopyrrolidine; 3-Cyano-3-((tert-butoxycarbonyl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-(Boc-NH)-3-CN-pyrrolidine; tert-Butyl 3-cyano-3-((tert-butoxycarbonyl)amino)pyrrolidine-1-carboxylate; 3-Amino-3-cyanopyrrolidine-1,3-dicarboxylic acid di-tert-butyl ester (protected form)
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(tert-Butoxycarbonylamino)-3-cyanopyrrolidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and correct stereochemistry, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.