Description

Methyl 6-Bromo-1H-Pyrazolo[4,3-B]Pyridine-3-Carboxylate CAS NO 1363380-66-8 is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs targeting various diseases.
• Kinase Inhibitor Development: Used in the research and synthesis of potential kinase inhibitors due to the privileged pyrazolopyridine structure.
• Agrochemical Research: Employed as an intermediate in the development of new crop protection agents and pesticides.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Methyl 6-Bromo-1H-Pyrazolo[4,3-B]Pyridine-3-Carboxylate
CAS No.	1363380-66-8
Molecular Formula	C8H6BrN3O2
Molecular Weight	256.06 g/mol
Synonyms	6-Bromo-1H-pyrazolo[4,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 6-bromo-1H-pyrazolo[4,3-b]pyridine-3-carboxylate; 1H-Pyrazolo[4,3-b]pyridine-3-carboxylic acid, 6-bromo-, methyl ester; 6-Bromo-1H-pyrazolo[4,3-b]pyridine-3-carboxylate methyl ester; Methyl 6-bromopyrazolo[4,3-b]pyridine-3-carboxylate; 1363380-66-8; Methyl 6-bromo-1H-pyrazolo[4,3-b]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-Bromo-1H-Pyrazolo[4,3-B]Pyridine-3-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.