Description

cis-3-(Boc-Amino)-4-(Trifluormethyl)Piperidine is a high-purity, protected piperidine derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, offering a versatile scaffold for constructing complex molecules with a trifluoromethyl group, a key motif for modulating pharmacokinetic properties. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Peptidomimetics & PROTACs: Serves as a constrained amino acid surrogate in the design of peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Ligand & Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes to study biological pathways and enzyme function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis services catering to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	cis-3-(Boc-Amino)-4-(Trifluormethyl)Piperidine
CAS No.	1363378-20-4
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	cis-1-Boc-3-Amino-4-(Trifluoromethyl)Piperidine; tert-Butyl (3R,4S)-3-Amino-4-(trifluoromethyl)piperidine-1-carboxylate; (3R,4S)-1-(tert-Butoxycarbonyl)-4-(trifluoromethyl)piperidin-3-amine; (3R,4S)-1-Boc-4-(Trifluoromethyl)piperidin-3-amine; Boc-3-Amino-4-CF3-Piperidine (cis); cis-3-Amino-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-Amino-4-(Trifluoromethyl)piperidine
EINECS	Contact for details

Quality Control

Our cis-3-(Boc-Amino)-4-(Trifluormethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.