Description

(2R,4R)-Ethyl 1-Boc-4-Hydroxypiperidine-2-Carboxylate is a high-purity, chiral piperidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceutical candidates, particularly in the synthesis of complex molecules with specific stereochemical requirements. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent drug candidates, including protease inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to introduce stereochemically defined piperidine motifs.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in catalytic asymmetric transformations to construct complex chiral architectures.
• Peptidomimetics Development: Integral for creating peptide-like compounds with enhanced metabolic stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds under cGMP conditions.

Basic Information

Product Name	(2R,4R)-Ethyl 1-Boc-4-Hydroxypiperidine-2-Carboxylate
CAS No.	1363378-14-6
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	Ethyl (2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate; 1-Boc-4-hydroxy-D-proline ethyl ester; (2R,4R)-1-Boc-4-hydroxypiperidine-2-carboxylic acid ethyl ester; 1-N-Boc-trans-4-hydroxy-D-proline ethyl ester; trans-4-Hydroxy-D-proline-1-Boc ethyl ester; (2R,4R)-4-Hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylic acid ethyl ester; BOC-D-Hyp-OEt; BOC-trans-4-Hydroxy-D-proline ethyl ester
EINECS	Contact for details

Quality Control

Our (2R,4R)-Ethyl 1-Boc-4-Hydroxypiperidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.