Description

5-Iodo-2-(Trifluoromethoxy)Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring both iodine and a trifluoromethoxy group, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Heck) due to the reactive iodine moiety, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry: Valuable for introducing the trifluoromethoxy group into target molecules, a motif known to improve metabolic stability and lipophilicity in drug candidates.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and scale-up projects requiring specialized halogenated heterocycles.

Basic Information

Product Name	5-Iodo-2-(Trifluoromethoxy)Pyridine
CAS No.	1361696-40-3
Molecular Formula	C6H3F3INO
Molecular Weight	288.99 g/mol
Synonyms	2-(Trifluoromethoxy)-5-iodopyridine; 5-Iodo-2-(trifluoromethoxy)pyridine; 5-Iodo-2-(trifluoromethoxy)pyridine; Pyridine, 5-iodo-2-(trifluoromethoxy)-; 1361696-40-3; 5-Iodo-2-trifluoromethoxypyridine; 2-Trifluoromethoxy-5-iodopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2-(Trifluoromethoxy)Pyridine is manufactured and tested under a strict quality management system. We guarantee high purity and consistency to meet the exacting standards of research and industrial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.