Description

6-(Trifluoromethoxy)Pyridin-3-Ol is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. This compound matters for its unique trifluoromethoxy substituent, which imparts enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring fluorine-containing aromatic units.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and the creation of novel chemical libraries.
• Ligand and Catalyst Design: Useful for constructing complex chelating ligands and organocatalysts in asymmetric synthesis.

Basic Information

Product Name	6-(Trifluoromethoxy)Pyridin-3-Ol
CAS No.	1361494-43-0
Molecular Formula	C6H4F3NO2
Molecular Weight	179.10 g/mol
Synonyms	3-Hydroxy-6-(trifluoromethoxy)pyridine; 6-(Trifluoromethoxy)-3-pyridinol; 5-Hydroxy-2-(trifluoromethoxy)pyridine; 3-Pyridinol, 6-(trifluoromethoxy)-; 6-Trifluoromethoxypyridin-3-ol; 2-(Trifluoromethoxy)-5-hydroxypyridine
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)Pyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.