Description

Ethyl 5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylate is a high-purity, fluorinated pyrazolopyridine derivative serving as a critical advanced pharmaceutical intermediate. This compound is valued for its precise molecular architecture, enabling the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for creating new fluorinated APIs with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Utilized as a reference standard or probe molecule in biochemical assays and pharmacological studies.

Basic Information

Product Name	Ethyl 5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylate
CAS No.	1361232-72-5
Molecular Formula	C₁₇H₁₃F₂N₃O₂
Molecular Weight	329.30 g/mol
Synonyms	5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester; Ethyl 5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridine-3-carboxylate; 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, 5-fluoro-1-[(2-fluorophenyl)methyl]-, ethyl ester; UNII-7K7Y1F5A16; 7K7Y1F5A16; SCHEMBL21806227; BDBM50389373; AKOS025147064
EINECS	Contact for details

Quality Control

Our Ethyl 5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with stringent pharmaceutical-grade standards. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.