Description

Cyclohexaneacetic Acid, α-[(2-Pyrazinylcarbonyl)Amino]-, (αr)- is a high-purity, non-natural amino acid derivative featuring a chiral center and a pyrazine-based acyl protecting group. This compound matters as a sophisticated pharmaceutical intermediate or chiral building block for the synthesis of complex bioactive molecules, where its specific stereochemistry and functional groups are critical for activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on novel drug candidates, particularly in peptide mimetics and targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to incorporate constrained, cyclohexyl-based structures into peptide analogs to enhance metabolic stability and binding affinity.
• Chemical Biology Probes: Acts as a building block for creating labeled compounds or probes to study biological pathways and enzyme interactions.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.
• Protecting Group Strategy: The 2-pyrazinylcarbonyl (Pz) group can function as an amine-protecting group in multi-step synthetic sequences.
• Ligand Development: Potential use in the design of novel ligands for catalysis or molecular recognition applications.

Basic Information

Product Name	Cyclohexaneacetic Acid, α-[(2-Pyrazinylcarbonyl)Amino]-, (αr)-
CAS No.	1359843-82-5
Molecular Formula	C₁₃H₁₇N₃O₃
Molecular Weight	263.29 g/mol
Synonyms	(R)-2-((Pyrazine-2-carboxamido)methyl)cyclohexane-1-carboxylic Acid; (αR)-α-[[(2-Pyrazinyl)carbonyl]amino]cyclohexaneacetic Acid; (R)-2-((Pyrazine-2-carboxamido)methyl)cyclohexanecarboxylic Acid; (1R,2R)-2-((Pyrazine-2-carboxamido)methyl)cyclohexanecarboxylic Acid (relative stereochemistry); Pz-(R)-Cha-OH; Fmoc-(R)-2-amino-2-cyclohexylacetic Acid Pyrazine Amide Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to verify identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Production can be aligned with cGMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.