Description

1-(Pyridin-4-Ylmethyl)-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group. This compound is critical for modern drug discovery, particularly in the synthesis of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is primarily sought by research institutions and pharmaceutical manufacturers developing novel therapeutics, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds in medicinal chemistry and process development.
• Drug Discovery Research: Used in high-throughput screening and the construction of compound libraries for target identification and lead optimization.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and cellular pathways.
• Material Science Research: Potential precursor for creating novel organic electronic materials or metal-organic frameworks (MOFs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(Pyridin-4-Ylmethyl)-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazine
CAS No.	1358953-46-4
Molecular Formula	C24H34BN3O2
Molecular Weight	407.36 g/mol
Synonyms	4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)(pyridin-4-ylmethyl)amino)piperidine (tautomeric form); 1-[(Pyridin-4-yl)methyl]-4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-1-(pyridin-4-ylmethyl)piperazine; Boronic acid, B-[4-[[4-[(4-pyridinylmethyl)-1-piperazinyl]methyl]phenyl]-, 1,3,2-dioxaborolane, 4,4,5,5-tetramethyl- ester; 1358953-46-4; BCP Pinacol Ester Intermediate; 4-Pyridylmethyl Piperazine Boronate Ester
EINECS	Contact for details

Quality Control

Our 1-(Pyridin-4-Ylmethyl)-4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure to air is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.