Description

2-Bromo-5-Fluoro-3-(Methylsulfonyl)Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for introducing specific bromo, fluoro, and methylsulfonyl functional groups into target molecules with precision. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogen and sulfone motifs for bioactivity.
• Material Science: Serves as a precursor for functionalized ligands and monomers in the creation of advanced polymers and electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions to form complex biaryl structures.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization due to its ability to modulate electronic properties and binding affinity.
• Chemical Biology: Used as a probe or tag in the development of chemical tools for studying biological systems and target identification.

Basic Information

Product Name	2-Bromo-5-Fluoro-3-(Methylsulfonyl)Pyridine
CAS No.	1357945-20-0
Molecular Formula	C7H5BrFNO2S
Molecular Weight	266.09 g/mol
Synonyms	2-Bromo-5-fluoro-3-(methylsulfonyl)pyridine; 3-Bromo-6-fluoro-2-(methylsulfonyl)pyridine; 5-Fluoro-2-bromo-3-methylsulfonylpyridine; Pyridine, 2-bromo-5-fluoro-3-(methylsulfonyl)-; 1357945-20-0; 2-Bromo-5-fluoro-3-methanesulfonylpyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoro-3-(Methylsulfonyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.