Description

2-Bromo-3-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of organic electronic materials, such as OLED emitters and charge-transport layers.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing sophisticated ligands and organometallic catalysts.
• Chemical Biology Probes: Enables the labeling and study of biological targets through bioconjugation and probe synthesis.
• Academic & Process R&D: A versatile reagent for method development and scaling novel synthetic routes in research laboratories.

Basic Information

Product Name	2-Bromo-3-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1357387-81-5
Molecular Formula	C12H17BBrNO3
Molecular Weight	314.00 g/mol
Synonyms	2-Bromo-3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Boronic acid, 2-bromo-3-methoxypyridine-, 1,3,2-dioxaborolane ester; 2-Bromo-3-methoxypyridine-4-boronic acid pinacol ester; (2-Bromo-3-methoxypyridin-4-yl)boronic acid pinacol ester; 1357387-81-5; 2-Bromo-3-methoxy-4-pyridineboronic acid pinacol ester.
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced intermediates and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.