Description

2-Ethynyl-Pyridin-4-Ylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core and ethynyl amine functional group. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of targeted small-molecule therapeutics. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis: Serves as a valuable reagent for constructing complex heterocyclic frameworks via Sonogashira and other cross-coupling reactions.
• Bioconjugation: The ethynyl group enables click chemistry applications for labeling and conjugating biomolecules in chemical biology.
• Agrochemical Development: Potential use as an intermediate in the research and development of new crop protection agents.
• Material Science: Exploration as a monomer or functional additive for creating specialized polymers with unique electronic properties.

Basic Information

Product Name	2-Ethynyl-Pyridin-4-Ylamine Hydrochloride
CAS No.	1357353-33-3
Molecular Formula	C7H7ClN2
Molecular Weight	154.60 g/mol
Synonyms	4-Amino-2-ethynylpyridine hydrochloride; 2-Ethynylpyridin-4-amine hydrochloride; 2-Ethynyl-4-pyridinamine hydrochloride; 4-Pyridinamine, 2-ethynyl-, hydrochloride; 2-Ethynyl-4-aminopyridine HCl; 2-Ethynyl-4-pyridinylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-Pyridin-4-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.