Description

1-Aminomethyl-2-Oxa-5-Aza-Bicyclo[2.2.1]Heptane-5-Carboxylic Acid tert-Butyl Ester is a sophisticated bicyclic amino acid derivative, serving as a critical building block in advanced organic synthesis. Its unique constrained scaffold is engineered to impart specific conformational properties to target molecules, enhancing their biological activity and metabolic stability. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel peptide mimetics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and GPCR-targeted therapeutics.
• Peptidomimetic Design: Used to construct conformationally restricted peptide analogs to improve oral bioavailability and receptor selectivity.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides with unique modes of action.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study enzyme function and protein-protein interactions.
• Material Science: Potential monomer for synthesizing specialty polymers with tailored properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Aminomethyl-2-Oxa-5-Aza-Bicyclo[2.2.1]Heptane-5-Carboxylic Acid tert-Butyl Ester
CAS No.	1357351-98-4
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	tert-Butyl 1-(aminomethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate; 2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, 1-(aminomethyl)-, 1,1-dimethylethyl ester; 1-Aminomethyl-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester; Bicyclic Proline Derivative; Constrained Amino Acid Ester; (1R,4S)-1-(Aminomethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester (stereoisomer); Fmoc-AMOAC-OtBu precursor.
EINECS	Contact for details

Quality Control

Our 1-Aminomethyl-2-Oxa-5-Aza-Bicyclo[2.2.1]Heptane-5-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.